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Moreover, the combination therapy may not modify the disease progression and are not curative

Encephalopathy, which results in coloration in many basal ganglia regions including the globus pallidus, subthalamic nuclei, and cranial nerve nuclei, can be caused by both CNS types 1 and 2 [52]

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The use of NADPH in redox cycling also affects the cell because NADPH is required to catalyze the reduction of oxidized glutathione by glutathione reductase, which is an important antioxidant

Glucocorticoids inhibit the HPA axis by stimulating the endocannabinoid activity in the hypothalamus, amygdala, and hippocampus [43, 44]

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