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Discordance in mouse/human translation is certainly not unique to this system, as is well known in other settings for a number of reasons (188)

2022 Oct 19;15(10):1283

For instance, a rapid reduction of the disulfide can be caused by a second cysteine nearby, as happens in the active sites of glutaredoxin (Grx) or thioredoxin (Trx)

This ligand-directed approach reduces systemic toxicity, enhances drug bioavailability at the site of interest, and improves therapeutic outcomes, particularly in tumours with heterogeneous receptor expression profiles [117]

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Training performance often improves at this stage because recovery is genuinely faster