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We recently observed that mice lacking the M 1 muscarinic acetylcholine receptor developed RGC loss at advanced age, which went along with elevated ROS levels and increased mRNA expression for the prooxidative enzyme, NOX2, but decreased mRNA levels for the antioxidant enzymes, SOD1, GPx1 and HO1, suggesting that the M 1 receptor is involved in modulating redox pathways in the retina [436]

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Psychopharmacology (Berl) 234(19):29292939 Al-Nimer MSM, Mohammad TAM, Alsakeni RA (2018) Serum levels of serotonin as a biomarker of newly diagnosed fibromyalgia in women: its relation to the platelet indices

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By disrupting the FOXO4-p53 interaction, FOXO4-DRI, a specific FOXO4 blocker, selectively induced p53 nuclear exclusion and apoptosis in senescent Leydig cells