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Hyperglycemic stimulation of PKC- in atrial cardiomyocytes activates the NF-B/TGF- signaling pathway, leading to increased expression of pro-inflammatory and pro-fibrotic mediators such as TNF-, TGF-, and signaling molecules like p-IB, p38 MAPK, Cav1.2, and NCX

Lastly, we did not observe any particular pattern of enzyme essentiality or the degree of activation for early or late regulated enzymes of the pathway (Fig

Shift workers and frequent travelers Circadian rhythm disruption from rotating shifts or frequent time zone changes creates a specific type of sleep problem that melatonin alone handles poorly

DCC confers susceptibility to depression-like behaviors in humans and mice and is regulated by miR-218

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