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As a result, patients on long-term opioid therapy often experience more pain, even at the same or higher doses of opioids, necessitating further increases in dosage that perpetuate the cycle of hyperalgesia
Mazzoccoli, G
D.RoccaJ.HamadatS.Raisman-VozariR
Activation of toll-like receptor 5 in microglia modulates their function and triggers neuronal injury
[DOI] [PubMed] [Google Scholar] 47.Chiang S.C., Meagher M., Kassouf N., Hafezparast M., McKinnon P.J., Haywood R., El-Khamisy S.F
Apoptosis, on the other hand, is distinguished by the cleavage of certain substrates and the activation of caspases
