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Iron overload has been found to play a pathogenic role in cardio-cerebrovascular toxicity both in animal models and in patients with different CCVDs

doi: 10.3390/biom9080356

In the latter process, stress-induced activation of the GC-inducible molecule, TSC22D3 [glucocorticoid-induced leucine zipper (GILZ)] in tumour-infiltrating DCs, which inhibited type I interferon (IFN) responses in those cells and IFN- + T-cell activation, was suggested as a possible mechanism [24, 183]

Redox Signal 8 (7-8), 12951305

K., Pokharia, D