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Men on testosterone replacement therapy occupy a unique physiological space

Recent evidence suggests that the compartmentation of many enzymes associated with ROS processing or redox regulation is not as fixed as earlier concepts would suggest, and redox and other PTMs may facilitate re-localization of proteins to fulfil moonlighting functions (Foyer et al

(Lond) 40 , 452459 (2015)

coli Rosetta 2 cells overnight at 18C

Iron can produce lipid ROS through the Fenton reaction, causing lipid peroxidation and promoting cell death
