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This temporary effect is probably due to immune system activation, mediated by cytokines that interfere with the hypothalamo-pituitary-ovarian (HPO) axis

References Aminoff MJ (2024): Pharmacologic Management of Parkinsonism & Other Movement Disorders (Chapter 28)

A randomized (159), double-blind, placebo-controlled trial involving 46 adult SLE patients (23 in the synbiotic group, 23 in the placebo group) showed that 60 days of synbiotic supplementation significantly increased butyrate metabolism, reduced the pro-inflammatory cytokine IL-6, and inhibited the elevation of hs-CRP

Medicare population: observational analysis

(PubMed) Termanini B, Gibril F, Sutliff VE, Yu F, Venzon DJ, Jensen RT

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