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In parallel, dysfunction of cytoplasmic Pattern Recognition Receptors (PRRs) (e.g., retinoic acid-inducible gene I) impairs downstream type I interferon (IFN-I) signalling, resulting in diminished phagocytic capacity and blunted IFN-I responses [48]
This implies the presence of defects in DNA nick ligation and oxidative damage, and DNA repair mechanisms in FUS-associated ALS (Wang H

Copper homeostasis as a therapeutic target in amyotrophic lateral sclerosis with SOD1 mutations
V.LiuH.et al

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This approach may pave the way for enhanced therapeutic strategies targeting the neurodegenerative processes underlying Parkinsons disease
