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Allopurinol, febuxostat (XO inhibitors), probenecid, sulfinpyrazone, and benzbromarone (uricosuric drugs) are some of the drugs used to treat these conditions

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At its most basic, the ELF provides a physical barrier against many inhaled oxidants and an important component of host defense against pathogens

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T cell exhaustion is well documented in viral infections and various cancer settings and is hypothesized to arise at least in part due to chronic antigen stimulation, though the pathways leading to exhaustion, particularly in the cancer setting, remain incompletely defined (208)

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