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doi: 10.1038/s41417-020-0170-2 97 WuZGengYLuXShiYWuGZhangMet al

We have previously shown that the platinum accumulation differences between parental and resistant HCT116 cells increased over time 45 , strongly pointing towards a central impact of oxaliplatin efflux mechanisms, like GSH-conjugate transporters of the ABCC family 29,30,42

While GPCR signaling is essential for normal functioning of cells, continued signaling or overstimulation can be deleterious to the survival of cells or may lead to uncontrolled growth of cells as in cancer

Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification

Studies suggest that it may protect against toxin-induced DNA damage (Egner 2003

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