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All efficacy data referenced comes from published clinical trials and is provided for educational purposes

Unlike essential medical procedures, elective treatments are not typically covered by insurance

Sattler FR, et al

Canonical Mode of c-Met Activation Pattern The canonical mode of c-Met activation involves the binding of HGF to c-Met, which induces homodimerization and autophosphorylation of the cytoplasmic domain of c-Met and then triggers downstream signaling pathways, including the mitogen-activated protein kinase (MAPK)/extracellular signal-related kinase (ERK) (Pascale et al., 2016), p-38 (Lee et al., 2003), and the Akt/protein kinase B (PKB) (Zhang et al., 2018c) pathways (Figure 2)

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