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Specifically, glutaredoxin protects thiols by the transfer of electrons from NADPH to disulfide substrates and this cycle is connected with glutathione and glutathione reductase (48)

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Furthermore, in glioma (U251) cells, triptolide triggers G2/M phase arrest while promoting apoptosis and autophagy, associated with the activation of ROS/c-JNK signaling pathways and inhibition of AKT/mTOR signaling [1009]