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However, oral LC supplementation increases the levels of trimethylamine- N -oxide (TMAO) [12], which, as a pro-atherogenic factor, has been indicated to increase the risk of cardiovascular disease (CVD) [13], chronic kidney disease (CKD) [14], and even cancer [15]

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Ghanem and co-workers reported similar observations of increased antioxidant activity and improved blastocyst quality by way of higher embryo development rate and fewer number of apoptotic cells after supplementing LC (1.5 mM, equivalent to 0.3 mg/mL) in culture media of bovine blastocyst during the pre-implantation stage [67]