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Shi and coworkers, [299] found that Chlorogenic acid ameliorated the CCl 4 -induced fibrosis and liver inflammation in rats by downregulating the expression of TLR4/MyD88/NF-B pathway, which further coincided with the reduction of collagen I, -SMA, iNOS and COX-2 expression

Snyder EE, Walts B, Prusse L, Chagnon YC, Weisnagel SJ, Rankinen T, et al

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As described above, the endothelium produces and activates molecules and inflammatory factors, which exit the bloodstream and reach the target tissue through the endothelium

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Methotrexate, an antifolate drug used in cancer therapy, is a known inhibitor of DHFR, the enzyme that catalyzes the conversion of DHF into THF, which is required for the de novo synthesis of nucleotides for both DNA and RNA