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Methylmalonic and propionic acidurias: management without or with a few supplements of specific amino acid mixture

Behnke AR

Improvement in mood and reduction of severe depression

However, the relationship is complex (e.g., genetic factors may have a significant role and need further study, as recently observed) and still controversial (e.g., significant heterogeneity exists between available studies), as evidenced by recent meta-analyses, requiring further deepening in larger clinical trials as well as mechanistic studies in the future to better elucidate this relationship [82,83,84,85]

Therefore, primary carnitine deficiency results in defective fatty acid -oxidation

Hellstrom WJ, Kendirci M, Matern R, Cockerham Y, Myers L, Sikka SC et al