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Mucous membrane pemphigoid MMP is the most common AISBD seen in dogs, accounting for 48% of cases, with German shepherd dogs overrepresented (41)
Under oxidative stress conditions, NRF2 separates from Keap1 and activates the expression of downstream target genes containing antioxidant response elements (ARE), such as iron heavy chain protein (FTH1) and iron light chain protein (FTL), promoting GSH synthesis and regenerating NADPH to exceed ROS production (83)
Therefore, MnO 2 NPs might have immense potential for treating EGFR-TKI-resistant NSCLC in both normoxic and hypoxic conditions
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Biomedicines 13:1913
CoQ10 also promotes the fibroblast proliferation 49
