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While the clinical phenotype observed in Papillon-Lefvre syndrome (PLS) necessitates careful monitoring of skin and periodontal health during DPP1 inhibition therapy, clinical trials have shown these adverse events occur at low frequencies (1%4%) and are predominantly mild to moderate in severity

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Nanoparticles can be engineered to cross the BBB via receptor-mediated transcytosis or adsorptive-mediated transcytosis, or to bypass the BBB altogether through alternative routes such as intranasal delivery, as described in-depth in Section 4.3