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This is the reason that GSH varies less in the menstrual cycle than the steady states of GSH would suggest GSH: glutathione Because GSH changes very slowly when estradiol and S change, the GSH concentration at each time is a weighted average of both low and high GSH concentrations corresponding to many different S values

[i] As an antioxidant, glutathiones primary role is to protect your cells from free radical damage

Lancet 309 , 345349 (1977)

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Short-term irritation, if it occurs, doesn't negate long-term benefits

(More information) Clinical signs of riboflavin deficiency include skin disorders, angular stomatitis, cheilosis, glossitis, and corneal vascularization