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doi: 10.1074/jbc.272.25.15661

It is a highly reactive toxic metabolite formed by cytochrome P450 2E1 and is responsible for the hepatocellular injury that occurs with paracetamol toxicity

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this replenishes peroxidation-prone lipids for membranes and can either be counterbalanced by antioxidant systems or, when these fail, heighten susceptibility to lipid peroxidation 43
Dihexa increased the expression of PI3K and p-AKT (Figure 5AC)

You need to be cautious if youre also taking a potentially toxic medicine such as cyclosporine
