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It is plausible that both routes operate in parallel, with spatial, temporal, and metabolite-specific dynamics shaping functional outcomes

Furthermore, the weight loss induced by tirzepatide appears to be primarily due to a greater reduction in fat mass compared to metabolically active lean mass, resulting in a favorable redistribution of abdominal ectopic adipose tissue and a marked reduction in waist circumference and intrahepatic fat [54]

(2020) 219:e202009128

Ames Test (Bacterial Reverse Mutation Test): Why, When, and How to Use

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