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Although c-MET inhibitors can influence HGF/c-MET signal transduction by inhibiting the abnormal activation of c-MET, some studies have shown that when MET inhibitors are used alone, they cannot significantly improve the prognosis of patients

However, Cagrilintide failed to induce significant cFos activation in RAMP1/3 KO mice, whereas sCT retained its ability to do so, likely via residual AMY2R signaling

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doi:10.1177/2331216518821449

Ohnishi et al., 2008)