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CRC has multifaceted origins, including poor lifestyle and dietary habits, disorders in intestinal flora, and abnormal immune response mechanisms [4-6]

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In an open-label RCT ( n = 96), oral administration of melatonin tablets (3 mg/d, 1 h before sleep, for 7 days) with standard treatment, substantially improved sleep quality and blood O 2 saturation parameters in hospitalized COVID-19 patients 667

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