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NNMT inhibitors are selective and do not impact related methyltransferases or enzymes in the NAD + salvage pathway The selectivity of NNMT inhibitors was confirmed by testing against a panel of structurally similar methyltransferases and two enzymes in the NAD + salvage pathway (NAMPT and SIRT1

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When SNC-80 and ARM-390 are chronically administrated, tolerance to analgesia develops and is dependent on endocytosis with SNC80 but not for ARM-390

doi: 10.1007/s12011-012-9491-9