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Another fusion protein targeting PD-L1 and TGF-, SHR1701, is being investigated in a phase II trial in combination with cyclin-dependent kinase 4/6 inhibitor in patients with hormone receptor-positive, HER2-negative, endocrine-resistant advanced breast cancer (NCT04355858)

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Its verified that pharmacological blockade with V-9302 could result in attenuated cancer cell growth and proliferation, increased cell death and oxidative stress in lung cancer cell (22)

They also intimately promote the formation of TJs present in between the ECs

[Abstract]2025 Sep 2;37(9):1907-1925.e14

Hair manifestations of endocrine diseases: a brief review