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Methods: Patients with CID were enrolled in this study and divided into the CID group [Generalized Anxiety Disorder-7 (GAD-7) score 30 min, (3) difficulty staying asleep, (4) waking up early, (5) daytime sleepiness, (6) impaired daytime function, (7) sleep difficulties and daytime function impairment lasting more than 3 days a week for more than 3 months, and (8) a Patient Health Questionnaire-9 (PHQ-9) score 5 with poor sleep quality

Moreover, it is impossible to carry out randomized or crossover designs

Portosystemic Shunt (also known as liver shunt) Portosystemic shunts are abnormal communications between the portal and systemic venous system which allows intestinal blood to be delivered to the systemic circulation prior to hepatic detoxification

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