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Statements Author contributions WY: Conceptualization, Visualization, Writing original draft, Writing review & editing

doi: 10.1016/j.theriogenology.2019.04.015 72 WuCZhangYShenQZhouZLiuWHuaJ

Over two years, CIPN was statistically significantly worse after twenty-four weeks of ALC therapy [47]

These groups received intravenous treatments of oridonin, orid-liposome, orid-liposome-MAL, and TLR2 pep-orid-liposome at a dosage of 5 mg/kg (equivalent to the active ingredient of oridonin), with PBS serving as the control, administered every other day

Many treatment modalities have been developed to restore the immune tolerance and immmunoregulatory balance in autoimmune rheumatic diseases, including the use of peptide-based therapeutics or the use of nanoparticles-based nanotechnology