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In a 2-year trial involving patients with type 2 diabetes mellitus (T2DM) and high cardiovascular risk, more events of diabetic retinopathy complications occurred in patients treated with semaglutide 0.5 and 1 mg once weekly injections (3%) compared to placebo (1.8%)

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doi: 10.1021/acs.biochem.8b00561 97 PortilloFVazquezJPajaresMA

(2000) The Journal of Biological Chemistry Mechanistic study demonstrating AOD 9604 directly activates hormone-sensitive lipase and stimulates lipolysis in isolated human adipocytes

This is usually not more than 1 mL per minute