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A decrease in total globulin can indicate an immune deficiency or lead poisoning, while high levels can result from infection, inflammation, vascular disorders, liver disease, IBD, or gammopathies like multiple myeloma

(2020) 3:e2018150

However, the decrease in metabolic efficiency also leads to reduced chemotaxis and phagocytic functions of microglia [6, 115]

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Based on the derived sensitivity and specificity, performance metrics including positive predictive value, negative predictive value, number needed to screen, and number proceeding to PET scan were calculated based on a prevalence of amyloid PET positivity of 25% 31