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In considering the possibility of a high-folatelow-vitamin B-12 interaction, it is important not to conflate the metabolic and public health aspects of this issue

[DOI] [PubMed] [Google Scholar] 102.Polonikov A

James SJ, Rose S, Melnyk S, Jernigan S, Blossom S, Pavliv O, Gaylor DW: Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism

As well as causing B12 deficiency, an increase in methylmalonic acid occurs, which is thought to result in loss of myelin in the peripheral nerves and, consequently, neuropathy, which may be symptomatic as early as 2 years into metformin treatment

Adverse Effects: Mild pain or redness at the injection site, very rare systemic reactions

Low dose alpha-methyl-para-tyrosine (AMPT) in the treatment of dystonia and dyskinesia