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Squalene is a naturally occurring part of our sebum, contributing in maintaining the hydro-lipid film that protects the epidermis: it prevents dryness without being greasy or clogging the pores

In fact, according to docking simulations, propranolol, a lipophilic small molecule with an aromatic ring and a secondary aliphatic amine, seems to interact with aspartate, glutamate, and phenylalanine residues (Figure 4) [36]

Moreover, mounting evidence has demonstrated the feasibility of several types of CPPs, including TAT-PTD, TCTP-PTD, polyarginine, and penetratin and analogs thereof (Table 1), in the transepithelial delivery through nasal and intestinal epithelium (

Epidermal melanocytes, owing to their specialized role in melanin synthesis, exhibit a heightened susceptibility to elevated ROS production, a phenomenon accentuated by solar exposure during the tanning process and instances of inflammation, subsequently culminating in post-inflammatory hyperpigmentation 17

Vitamin C: Glutathione and Vitamin C have a unique relationship

Studies in mice suggest that KD consumption differentially impacts neuronal and astrocytic gene transcription, influencing mitochondrial function and inflammation, potentially associating with neurodegenerative diseases [48]