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However, conditions affecting the gastrointestinal tractincluding pernicious anaemia, Crohn's disease, coeliac disease, or gastric surgerycan significantly impair absorption, necessitating alternative supplementation routes such as intramuscular hydroxocobalamin injections, which deliver B12 directly into the bloodstream

References: Ezzedine, K., Eleftheriadou, V., Whitton, M

This direct route guarantees 100% absorption and is particularly crucial when neurological symptoms or severe anemia require rapid treatment

It can affect any part of the GI tract and can create patchy areas of damage

If there is a scatter plot, I think that another variable that should be considered is the type of B12 injected