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The role of exogenous antioxidant supplementation remains controversial since meta-analyses have shown mixed results

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Hu S, Huang KM, Adams EJ, Loprinzi CL, Lustberg MB

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27 Thus, targeting activation of PKR in sickle RBCs to lower 2,3-DPG and increase ATP levels seems like a reasonable strategy to increase hemoglobin and decrease sickling and hemolysis

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