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The major classes of analgesics include nonsteroidal anti-inflammatory drugs (NSAIDs), opioid analgesics, local anesthetics, and gabapentinoids, each operating via distinct molecular mechanisms yet converging on the suppression of nociceptive signaling at the site of tissue injury, either along peripheral nerves or within central pain-processing pathways

292 In summary, the use of metformin as a potential inhibitor of NETs formation and NETosis shows promise in the treatment of GA

iScience 27 , 109530 (2024)

GSH and its derivates are widely involved in plant development and stress response, and GSH itself serves as a hub for the mechanisms of heavy metal detoxification, xenobiotics biodegradation and oxidative stress response [7, 9]

Apoptosis Many factors involved apoptosis under IH conditions, including oxidative stress, ER stress, and inflammation response (da Rosa et al., 2015