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4.2 Ferroptosis and rheumatoid arthritis Rheumatoid arthritis (RA) is the typical autoimmune disease that primarily targets the synovial membrane of the joints, resulting in the synovium transforming into a hyperplastic and invasive tissue that destroys cartilage and bone (128)

doi: 10.1016/j.fertnstert.2003.10.034

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In malignant tumors, IFN produced by CD8+ T cells increases with rising Gln concentrations, indicating that immunotherapy targeting tumors also relies on Gln-dependent activation of CD8+ T cells (12)

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