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15 They explain that vitamin C is a cofactor for the enzyme peptidylglycine -amidating monooxygenase (PAM), 137 the only known enzyme in humans capable of making essential modifications to peptide hormone precursors

doi: 10.1073/pnas.92.4.1232

Adding the positive control, digitonin, resulted in a large increase in cytotoxic signal

Therefore, complete simulation of metabolic processes would require inclusion of much more detailed consideration of inhibitory reactions

These observations were attributed to impairments of the phospho-inositol/phosphate kinase B pathway

Osman wishes to acknowledge the support of The Bryden Centre project (Project ID VA5048)