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The oxidative stress in mitochondria could be counteracted by IDH1-driven reductive carboxylation in the cytosol, followed by the transfer of citrate into the mitochondria, which was to be oxidized by IDH2 to generate NADPH [104]

Short-Term High-Dose Vitamin C and E Supplementation Attenuates Muscle Damage and Inflammatory Responses to Repeated Taekwondo Competitions: A Randomized Placebo-Controlled Trial. International Journal of Medical Sciences , vol

Novel tricyclic small molecule inhibitors of nicotinamide N-methyltransferase for the treatment of metabolic disorders
demonstrated that glutamine is required for intestinal cell proliferation by activating multiple MAPKs, including extracellular signal-regulated kinases (ERK1/2) and c-Jun N-terminal kinases (JNK1/2), in the rat intestinal mucosal cell line, IEC-6 [30] (Figure 1)
Gale MM, Crawford MA, Woodford MH