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Drug Deliv 2018, 25 (1), 448460

This liquid biopsy approach demonstrated that a number of pathways including aminoacyl tRNA biosynthesis, valine, leucine and isoleucine biosynthesis, alanine, aspartate, and glutamate metabolism, arginine biosynthesis, glycine, serine, and threonine metabolism demonstrate dysregulation in the breast cancer patients with brain metastasis

Glycolysis Tumor cells increase glycolysis to meet their proliferative energy needs, facilitating EMT

These effects are largely mediated by the melatonin receptors MT1 and MT2