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84 Because mitochondria have a central role in cellular energy production, it is plausible that mitochondria also have an important role in regulating lifespan in response to dietary restrictions

coli growth, a temperaturesensitive fabF fabA (Ts) mutant (Appendix Table S1), in which a shift to nonpermissive growth temperatures leads to UFA depletion, has been isolated (Cronan & Gelmann, 1973)
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The gating glutamate E203A mutant of AtCLCa abolished H + but not anion transport 6,29 , while the proton glutamate E270A mutant of AtCLCa eliminated both H + and anion transport 29

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The exact positioning of W1 is crucial for the enzymatic activity of Lm PC-PLC The conserved N-terminal residue W1, is firmly anchored in the active site cleft (Figs