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CONCLUSION Glutathione displays remarkable metabolic and regulatory versatility, which poses the tripeptide at the center stage of a multitude of cellular processes, including cell proliferation, differentiation, and death

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Despite these advances in understanding GPX4 biology, several important questions remain to be answered

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In solid tumors, the tumor microenvironment mainly consists of the tumor-associated stroma that includes infiltrating inflammatory and immune cells, resident fibroblasts, adipocytes, blood endothelial cells, and extracellular matrix (ECM) proteins [6]