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As STING expression is limited in neoplastic cell populations of gliomas and other CNS tumors, the mechanism of action for STING agonists has mainly focused on immune-mediated anti-cancer activities

As the pathological burden increases, this metabolic dysregulation may eventually evolve into hepatic fibrosis, cirrhosis, or even further development of hepatocellular carcinoma [75]

But it's still worth optimizing as part of a broader strategy

It is known that the ability to detoxify APAP varies greatly among different animal species [57]

10.1038/s41467-020-16092-0 6 AnsteeQ

The result is targeted mobilization of the most dangerous fat compartment
