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The decrease of neurotrophins, in serum and in CNS (33) has been associated with the formation of A and pTau plaques (3436)

It's also noteworthy that B12 supplementation repressed the expression of certain skin proteins in studies, leading to alterations in skin health

International Journal of Clinical Pharmacology Research 1990;10:1017

Table 3 illustrates summary findings of group differences in percent change from previous timepoints for each variable and measure

Lipid profile (triglycerides, cholesterol)

In animal models, C2 supplementation promoted neuroplasticity, synthesis of neurotrophic factors, modulation of glutamatergic dysfunction, reversal of neuronal atrophy in regions like the hippocampus and amygdala, and improvement in depression-like behavioral symptoms [20, 30, 57, 58]