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[] In the latter one, insulin activates ATP-sensitive potassium (K ATP ) channels in the outer membranes of neurons in the hypothalamus, and subsequently, generates an efferent vagal impulse to the liver (the hepatic branch of vagus nerve comprising both efferent fibers and afferent fibers) required for inhibiting hepatic glucose production [] [Figure 7]

10.3390/biom10111536 Biomolecules

Adv Nutr 2024;15(5):100221

Thanks to the peptide's action, pain antagonism occurs, which is based on its effect through the central dopaminergic system

This is supported by the recent finding that the phosphoenolpyruvate (PEP) cycle is associated with the GTP-SCS-catalysed reaction [65]
