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Anemia and peripheral neuropathy, distinct from diabetic neuropathy, can develop if B12 levels remain low
A study conducted in 2016 thus came to the following conclusion: If we had restricted the treatment of symptomatic patients to patients with both low serum levels and elevated metabolite levels, 63% of patients who responded well to the therapy would not have received treatment [] Only 16% of patients with good clinical improvement from vitamin B12 therapy had low serum levels and 54% of patients with good clinical improvement from vitamin B12 therapy had serum levels higher than 300 pg/mL. Some experts thus advise high-dose B12 treatment to treat all known nervous symptoms associated with B12 deficiency
PubChem CID: 44147413
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In a typical Western diet, a person obtains approximately 5 to 15 mcg of vitamin B 12 daily, much more than the recommended daily allowance of 2 mcg
