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Because of their instabilities and soluble natures, developments are required to enable their therapeutic use [19]

10.1523/JNEUROSCI.21-19-07455.2001 187 SeifertG.RehnL.WeberM.SteinhuserC

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However, much information may be gained from simple animal models that may be ultimately applied to mammals

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DCs comprise multiple subsets with distinct functions but can be broadly classified into two major subsets, myeloid DCs [including classical/conventional DCs (cDCs), which are further subdivided into classical type 1 DCs (cDC1s) and classical type 2 DCs (cDC2s), monocyte-derived DCs (MoDCs), and Langerhans cells] and plasmacytoid DCs (pDCs) ( in vivo : Flt3-L supports the development of cDCs and pDCs derived from bone marrow (BM) precursors, whereas GM-CSF contributes to the development of MoDCs, as well as inflammation-induced myeloid DCs ( Figure 1 )