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NAC provides cysteine, one of the three amino acids that makes up GSH

Therapeutic effect of adjunctive N -acetyl cysteine (NAC) on symptoms of chronic schizophrenia: a double-blind, randomized clinical trial

It seems, therefore, that natural selection has favoured the generation of a complex ROS signalling system above eliminating ROS from metabolism, which would have been the likely outcome if they were solely toxic

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Combination strategies also warrant exploration, including co-administration of apigenin and ellagic acid or their use alongside standard therapies such as metformin or letrozole to enhance efficacy and reduce drug-related side effects