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[DOI] [PMC free article] [PubMed] [Google Scholar] 142.Rasmussen J, Lund AM, Risom L, Wibrand F, Gislason H, Nielsen OW, Kober L, Duno M

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

Signaling pathways (e.g., NF-B, Akt, and MAPKs) and small signaling molecules (e.g., nitric oxide and carbon monoxide) are involved in inflammation-dependent activation of mitochondrial biogenesis by connecting inflammatory signals to the biogenesis machinery, centered on transcriptional factors and coactivators (220)

A 2011 study on postmortem brain samples, for instance, demonstrated low electron transport chain (ETC) activity levels in the cerebellum, frontal and temporal cortices of younger subjects (aged 410 years) when compared to age-matched controls (124)

However, it's important to check with a healthcare professional to tailor your supplement stack to your individual needs and goals
