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Through multi-metabolite synergies, these natural products target key axes such as AMPK/SREBP-1c (lipid synthesis) and AMPK/mTOR (autophagy), coordinately regulating lipid homeostasis and mitigating hepatic injury (Figure 1)

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Recent studies identify additional metabolites - including Lygodium microphyllum ( /CPT-1A pathway ( 6 Limitations of preclinical evidence and appraisal of translational gaps While current clinical management of NAFLD primarily relies on lifestyle modifications and metabolic regulation interventionsincluding insulin sensitizers, antioxidants, and lipid-lowering agentsthese approaches can delay disease progression but rarely reverse hepatic steatosis and fibrosis