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vascular endothelial growth factor (VEGF) and angiopoietin-1, leading to the induction of genes involved in angiogenesis and thus represent therapeutic targets for the inhibition of tumor angiogenesis [122]

They can not only promote the synthesis of plant secondary metabolites but also secrete bioactive defensive compounds [25, 26]

Known anti-persister strategies As many studies have found increased ROS levels and altered antioxidant pathways in melanoma persisters, several strategies have been developed using these characteristics as targets (Table 1)

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Further studies revealed that ANPEP stabilizes SLC3A2 at the plasma membrane by blocking its lysosome-dependent degradation mediated by membrane associated ring-CH-type finger 8 (MARCH8)