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Ayurvedic medicines like Triphala Guggulu and Pilex that contain neem ( Azadirachta indica ) together with haritaki ( Terminalia chebula ) and lajjalu ( Mimosa pudica ) provide a wide range of therapeutic benefits, which include stool regulation, systemic detoxification, and wound healing enhancement [5]

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Perestelo-Perez L

By reducing mitochondrial ROS production and enhancing bioenergetic efficiency, metformin decreases mtDNA damage and attenuates mtDNA-mediated activation of innate immune sensors such as the cGASSTING pathway and inflammasomes [205]

For leukoplakia, curcumin functions as an antioxidant by inhibiting ROS production, elevating salivary levels of vitamins C and D, protecting against lipid peroxidation and DNA damage, regulating cell proliferation, inhibiting nuclear factor-kappa B (NF-B), and preventing invasion and metastasis in the epithelium by suppressing excessive TGF receptor signaling (Rai et al., 2010

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